Bioavailability of aflatoxin B1 and ochratoxin A, but not fumonisin B1 or deoxynivalenol, is increased in starch-induced low ruminal pH in nonlactating dairy cows
D. Pantaya,1 D. P. Morgavi,2 M. Silberberg,2 F. Chaucheyras-Durand, 3 C. Martin,2, Suryahadi,4 K.G. Wiryawan, 4 and H. Boudra,5
Author Information
- UMRH, INRA, Vetagro Sup, 63122 Saint-Genès-Champanelle, France; Department of Animal Science, State Polytechnic Jember, Jember, Indonesia, 68121
- UMRH, INRA, Vetagro Sup, 63122 Saint-Genès-Champanelle, France.
- Lallemand Animal Nutrition, 31702 Blagnac Cedex, France; Unité de Microbiologie, INRA, 63122 Saint-Genès-Champanelle, France.
- Faculty of Animal Science, Bogor Agricultural University, Bogor, Indonesia, 16680
- UMRH, INRA, Vetagro Sup, 63122 Saint-Genès-Champanelle, France
DOI: https://doi.org/10.3168/jds.2016-11421
https://www.journalofdairyscience.org/article/S0022-0302(16)30717-2/fulltext
December 2016 Volume 99, Issue 12, Pages 9759–9767
Abstract
High-production dairy and beef systems require diets rich in starch. This practice may induce ruminal acidosis and also increase exposure to mycotoxins because starches in starch-rich diets are the main vehicles of mycotoxin contamination. The aim of this study was to investigate the effects of low ruminal pH on the bioavailability of 4 major mycotoxins [i.e., aflatoxin B1 (AFB1), ochratoxin A (OTA), deoxynivalenol (DON), and fumonisin B1 (FB1)]. Eight nonlactating dairy cows fitted with rumen cannulas were used in a double crossover experiment. The trial was divided into 4 periods with 2 periods per crossover. Cows were divided into 2 groups receiving a low (15% dry matter basis) and high-starch diet (30.8%) with and without live yeast supplementation (1 × 1010 cfu per cow) in the first and second crossover, respectively. At the end of each period, cows received a single dose of mycotoxin-contaminated feed containing 0.05, 0.2, 0.24, and 0.56 mg of AFB1, OTA, DON, and FB1 per kg of feed, respectively. The fecal and urinary excretion of mycotoxins and their metabolites was monitored for up to 48 h postdosing. As expected, ruminal pH decreased in cows fed the high-starch diet. The high-starch diet increased the bioavailability of OTA and AFB1. Urinary excretion of OTA 24 h after mycotoxin administration increased 3-fold in the high-starch diet, correlated with lower fecal excretion. Similarly, a decrease in fecal excretion of AFB1 was accompanied by an increase in urinary excretion of its major metabolite, aflatoxin M1, 48 h after mycotoxin administration. In contrast to AFB1 and OTA, the bioavailability of DON and FB1 remained unchanged. Yeast supplementation had no effect on the excretion balance of these 2 mycotoxins. In conclusion, these results show that high-starch diets increased the bioavailability of OTA and AFB1, most probably through the lowering effect on ruminal pH. This greater bioavailability potentially increases the toxic effects of these mycotoxins.
Key words:
mycotoxin, low ruminal pH, dairy cow, live yeast supplementation
I am not sure where you?re getting your info, but
great topic. I needs to spend some time learning much
more or understanding more.
Thanks for great information I was looking for this info for my mission. https://lascootershop.ca
Thank you for the good writeup. It in fact was a amusement account it. https://www.welldonefinition.com
What a fantastic article! This is so chock full of useful information I can’t wait to dig deep and start utilizing the resources you have given me.
Your exuberance is refreshing. Thanks for a great article! https://publissoft.com
Thank you for publishing this awesome article. I’m a long time reader but
I’ve never been compelled to leave a comment. I subscribed to your blog and shared
this on my Facebook. Thanks again for a great article! https://www.publissoft.mx
Thanks for publishing this awesome article. I’m a
long time reader but I’ve never been compelled to leave a comment.
I subscribed to your blog and shared this on my Facebook.
Thanks again for a great article! https://www.perform-art.com
Great article! Thank you 🙂 https://constructionlabrie.com/quelles-caracteristiques-devrait-avoir-entrepreneur-construction-montreal/
I?ve been browsing online more than 3 hours today, yet I never found any interesting article
like yours. It?s pretty
worth enough for me. In my view,
if all website owners and bloggers
made good content as you did, the net will be much more useful than ever before. https://actionmobile.ca
A person necessarily
lend a hand to make seriously articles
I might state. This is the first time I frequented your website
page and thus far? I amazed with the research you made to make this actual publish incredible.
Wonderful job!|
Heya i am for the primary time here. https://www.lmesthetique.ca
Hi would you mind letting me know which web host you?re utilizing?
I?ve loaded your blog in 3 different internet browsers
and I must say this blog loads a lot faster then most.
Can you recommend a good internet hosting provider at a
reasonable price? Thank you, I appreciate it! https://www.publissoft.es
Thanks for publishing this awesome article. I’m a long time reader
but I’ve never been compelled to leave a comment.
I subscribed to your blog and shared this on my Twitter.
Thanks again for a great article! https://www.entretienmenager-gtp.com
Its like you read my mind!
You seem to know a
lot approximately this, such as you wrote the guide
in it or something. I think that you just can do with some p.
c. to force the message house
a little bit, but instead of that, that is
great
blog. An excellent read.
I?ll certainly be back.|
I visited multiple websites except the audio quality for audio songs existing at this web page is in fact
superb.|
Hi, i read your blog from time to time and i own a similar one and i was just wondering if you get
a lot of spam responses? If so how do you protect against it, any plugin or anything you can recommend?
I get so much lately it?s driving me mad so any support is
very much appreciated.|
Greetings! Very useful advice in this particular post!
It is the little changes that will make the biggest changes.
Thanks for sharing!|
I absolutely love your website.. Very nice colors & theme.
Did you develop this amazing site yourself?
Please reply back as I?m hoping to create my very own website and would love to know where you
got this from or exactly what the theme
is called. Kudos! https://www.entreprisesjosemelo.ca
Greetings from Ohio! I?m bored at work so I decided to check
out your website on my iphone during lunch break.
I enjoy the info you present here and can?t wait to take a look when I get home.
I?m shocked at how fast your blog loaded on my
mobile .. I?m not even using WIFI, just 3G
.. Anyways, great site! https://tesgo.ca
Hi there, just wanted to mention, I enjoyed this post. It was practical.
Keep on posting! https://departement-ti.com/blogue-services-informatiques-pour-entreprises/news/la-securite-mobile
Hi there would you mind letting me know
which web host you?re working with? I?ve loaded your blog in 3 different web browsers and I must say this blog loads a lot quicker then most.
Can you suggest a good web hosting provider at a
honest price? Thanks
a lot, I appreciate it! https://www.josee-lemieux.com
Everyone loves it whenever people get together and share thoughts.
Great website, continue the good work! https://www.constructionlaurinvilleneuve.com
Everyone loves it when folks come together and share opinions.
Great site, stick with it! https://eleganzamagazine.com
Everyone loves it when individuals get together and share ideas.
Great blog, keep it up! https://www.acupuncturerive-sud.com/la-fatigue-de-lautomne/
Thank you for posting this awesome article. I’m a long time reader
but I’ve never been compelled to leave a comment. I subscribed to your blog and shared this on my Twitter.
Thanks again for a great post! https://www.ecoleesthetiquenf.ca/formations/soins-mains/
I just could not depart your web site prior to suggesting that I actually enjoyed the usual information an individual provide for your visitors?
Is going to be back often to check out new posts|
I wanted to thank you for this excellent read!! I certainly loved every bit of it.
I?ve got you book marked to look at new stuff you post? https://www.miniexcavationrbeaudet.com
Greetings! Very useful advice in this particular article!
It?s the little changes that will make the biggest changes.
Thanks a lot for sharing!| I absolutely love your site..
Great colors & theme. Did you build this web site yourself?
Please reply back as I?m wanting to create my own site and want to know where you got this
from or just what the theme is named.
Cheers! https://clindoeilmontreal.ca
Good Information, Thank for sharing. https://www.rapid3tires.com
Howdy, I believe your blog could possibly be having browser compatibility issues.
When I look at your site in Safari, it looks fine however, if opening
in I.E., it?s got some overlapping issues.
I simply wanted to give you a quick heads up!
Aside from that, excellent site! https://ultrascoot.com
Thank you for publishing this awesome article. I’m
a long time reader but I’ve never been compelled to leave a comment.
I subscribed to your blog and shared this on my Twitter.
Thanks again for a great article! https://aldus.ca